Local drug delivery to brain tumor
نویسندگان
چکیده
منابع مشابه
Brain tumor-targeted drug delivery strategies
Despite the application of aggressive surgery, radiotherapy and chemotherapy in clinics, brain tumors are still a difficult health challenge due to their fast development and poor prognosis. Brain tumor-targeted drug delivery systems, which increase drug accumulation in the tumor region and reduce toxicity in normal brain and peripheral tissue, are a promising new approach to brain tumor treatm...
متن کاملDrug Delivery to Brain Tumor: Challenges and Recent Developments
Drug delivery for brain tumors is a questionable subject which is the major barrier in treatment. Nowadays, a lot of proposals have been developed to increase the amount of intravascular drug reaching the tumor. All drugs have a common disadvantage, only a small amount of delivered drug actually reaches the tumor. The systemic toxicity is the main doselimiting factor. When we are given directly...
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BACKGROUND The blood-brain tumor barrier (BTB) significantly impedes delivery of most hydrophilic molecules to brain tumors. Several promising strategies, however, have been developed to overcome this problem. METHODS We discuss several drug delivery methods to brain tumor, including intracerebroventricular, convection enhanced delivery, BBB/BTB disruption, and BTB permeability modulation, wh...
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Periodontal diseases are considered infection of the periodontium, because there is bacterial etiology, an immune response, and tissue destruction. Putative pathogens associated with periodontal diseases are susceptible to a variety of antiseptics and antibiotics. Methods employed to convey antimicrobial agents into periodontal pockets have included rinsing, irrigation, systemic administration,...
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As the people have been suffering from many CNS disorders like Multiple sclerosis, Alzheimer’s disease, Parkinson’s disease many drugs have been developed but they failed in showing the concentration required for action. But nose to brain drug delivery the drug directly enter into the brain. The objective of this review is to provide overview of nose on an physiological, anatomical and, barrier...
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ژورنال
عنوان ژورنال: Lab Animal
سال: 2019
ISSN: 0093-7355,1548-4475
DOI: 10.1038/s41684-019-0453-0